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Results for "

anti-proliferative activity

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (4) ADC Cytotoxin (3) Adenosine Receptor (1) Adrenergic Receptor (1) Akt (5) Aldehyde Dehydrogenase (ALDH) (2) Amino Acid Derivatives (1) Aminopeptidase (1) AMPK (3) Amyloid-β (1) Anaplastic lymphoma kinase (ALK) (2) Androgen Receptor (3) Antibiotic (20) Apoptosis (157) Atg7 (1) Atg8/LC3 (1) ATM/ATR (2) Aurora Kinase (3) Autophagy (20) Bacterial (32) Bcl-2 Family (9) Bcr-Abl (5) Biochemical Assay Reagents (1) BRK (1) Btk (7) c-Fms (1) c-Kit (4) c-Met/HGFR (9) c-Myc (2) Carbonic Anhydrase (12) Casein Kinase (3) Caspase (10) CD73 (1) CDK (29) Ceramidase (1) CFTR (1) Checkpoint Kinase (Chk) (2) Cholinesterase (ChE) (1) COX (3) Cryptochrome (1) CXCR (1) Cytochrome P450 (3) Deubiquitinase (2) Dihydroorotate Dehydrogenase (1) DNA Alkylator/Crosslinker (1) DNA-PK (3) DNA/RNA Synthesis (12) Dopamine Receptor (6) Drug Metabolite (1) Drug-Linker Conjugates for ADC (1) DYRK (2) EBV (1) EGFR (28) Endogenous Metabolite (5) Epigenetic Reader Domain (16) ERK (5) Estrogen Receptor/ERR (2) Eukaryotic Initiation Factor (eIF) (2) FAK (6) Fat Mass and Obesity-associated Protein (FTO) (1) Fatty Acid Synthase (FASN) (1) Ferroptosis (2) FGFR (4) Flavivirus (1) FLT3 (12) Fungal (10) Gli (1) Glutaminase (2) Glutathione Peroxidase (2) HDAC (20) Hedgehog (3) HIF/HIF Prolyl-Hydroxylase (4) Histone Acetyltransferase (4) Histone Demethylase (8) Histone Methyltransferase (7) HIV (2) HPV (1) HSP (7) HSV (2) HuR (1) ICMT (1) IFNAR (1) IGF-1R (1) Influenza Virus (3) Interleukin Related (1) Isocitrate Dehydrogenase (IDH) (1) Isotope-Labeled Compounds (4) Itk (1) JAK (9) JNK (1) Keap1-Nrf2 (2) Kinesin (3) Lactate Dehydrogenase (1) Ligands for Target Protein for PROTAC (1) Lipoxygenase (1) LXR (1) mAChR (1) MALT1 (1) MAP3K (1) MAPKAPK2 (MK2) (1) MDM-2/p53 (7) MEK (3) MELK (1) Methionine Adenosyltransferase (MAT) (1) MicroRNA (1) Microtubule/Tubulin (36) Mitochondrial Metabolism (5) Mitophagy (2) MMP (7) Monoamine Oxidase (1) Mps1 (3) mTOR (2) Necroptosis (2) NF-κB (3) NO Synthase (2) Notch (1) Nucleoside Antimetabolite/Analog (3) Oxidative Phosphorylation (1) P-glycoprotein (1) p38 MAPK (2) p62 (1) PAK (1) Parasite (8) PARP (7) PDGFR (3) PERK (2) Phosphatase (3) Phosphodiesterase (PDE) (5) PI3K (11) Pim (5) PKC (4) Platelet-activating Factor Receptor (PAFR) (1) Polo-like Kinase (PLK) (8) Potassium Channel (1) PROTACs (19) Proteasome (2) Proton Pump (1) Pyruvate Kinase (1) Raf (5) Ras (9) Reactive Oxygen Species (15) RET (1) ROR (1) SARS-CoV (4) SHP2 (1) Sirtuin (1) Smo (2) Somatostatin Receptor (6) SphK (1) Src (3) SRPK (1) STAT (10) Steroid Sulfatase (1) Syk (1) TAM Receptor (1) Topoisomerase (17) Trk Receptor (8) TrxR (1) Tyrosinase (3) VD/VDR (1) VEGFR (8) WDR5 (1) Wnt (2) YAP (2) β-catenin (1)
By Research Areas:	Cancer (557) Cardiovascular Disease (7) Endocrinology (5) Infection (50) Inflammation/Immunology (35) Metabolic Disease (14) Neurological Disease (17)
Click Chemistry:	Alkynes (2)

608

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W013032A

Oxamic acid sodium 3 Publications Verification Sodium oxamate	Lactate Dehydrogenase Apoptosis	Cancer
Oxamic acid (oxamate) sodium salt is a lactate dehydrogenase-A (LDH-A) inhibitor. Oxamic acid sodium salt shows anti-tumor activity, and anti-proliferative activity against cancer cells, and can induce apoptosis .

HY-15587

L82	DNA/RNA Synthesis	Cancer
L82 is a selective and uncompetitive DNA ligase 1 (DNA Lig1) inhibitor (hLig1 IC₅₀=12 μM). L82 shows anti-proliferative activity to breast cancer cells .

HY-N10393

Vibsanin A	PKC HSP	Cancer
Vibsanin A, a protein kinase C (PKC) activator, exhibits anti-proliferative activity against human cancer cell lines. Vibsanin A is also a HSP90 inhibitor .

HY-152945

Antiproliferative agent-22	NF-κB	Cancer
Antiproliferative agent-22 (compound 2) is an anticancer agent. Antiproliferative agent-22 shoes anti-proliferative activities against MCF-7, MDA-MB-231 and MDA-MB-468 cells with IC₅₀ values of 6.2 μM, 3.3 μM and 3.3 μM, respectively .

HY-143250

Tubulin inhibitor 12	Microtubule/Tubulin	Cancer
Tubulin inhibitor 12 (Hit 9) is a novel tubulin inhibitor (IC₅₀=25.3 μM). Tubulin inhibitor 12 shows anti-tumor activity and anti-proliferative activity .

HY-17037

Pirenzepine dihydrochloride 1 Publications Verification LS 519; Pirenzepin dihydrochloride; Gastrozepin dihydrochloride	mAChR	Metabolic Disease Cancer
Pirenzepine (LS 519) dihydrochloride is a selective M1 mAChR (muscarinic acetylcholine receptor) antagonist. Pirenzepine dihydrochloride reduces gastric acid secretion and reduces muscle spasm, can be used in peptic ulcers research. Pirenzepine dihydrochloride shows anti-proliferative activity to cancer cells .

HY-150694

HDAC6-IN-11	HDAC	Cancer
HDAC6-IN-11 (Compound 9) is a selective HDAC6 inhibitor with the IC₅₀ value of 20.7 nM. HDAC6-IN-11 has more than 300-fold selectivity over HDAC other isoforms. HDAC6-IN-11 shows anti-proliferative activities against cancer cells .

HY-P99218

Robatumumab Sch 717454; 19D12	IGF-1R	Cancer
Robatumumab (Sch 717454) is an anti-human IGF-1R (insulin-like growth factor receptor-1) antibody. Robatumumab shows anti-tumor activity and anti-proliferative activity to cancer cells. Robatumumab can be used in osteosarcoma and Ewing sarcoma research .

HY-N2959

Brevilin A 3 Publications Verification	JAK STAT Apoptosis Autophagy	Cancer
Brevilin A is an orally active STAT3/JAK inhibitor (STAT3 IC₅₀= 10.6 µM). Brevilin A shows anti-tumor activity, anti-proliferative activity to cancer cells, and can induce apoptosis and autophagy .

HY-150595

HDAC6-IN-10	HDAC Microtubule/Tubulin	Cancer
HDAC6-IN-10 is a highly selective HDAC6 inhibitor with the IC₅₀ of 0.73 nM. HDAC6-IN-10 has 144~10941-fold selectivity over other HDAC isoforms. HDAC6-IN-10 shows anti-proliferative activities against multiple myeloma cells .

HY-146209

Tubulin polymerization-IN-13	Microtubule/Tubulin Apoptosis	Cancer
Tubulin polymerization-IN-13 (Compound 4f) is a tubulin polymerization inhibitor (IC₅₀=0.37 μM). Tubulin polymerization-IN-13 shows anti-proliferative activity against cancer cells, induces apoptosis and potential antivascular activity .

HY-122844

Ifebemtinib BI-853520; IN-10018	FAK	Cancer
Ifebemtinib (BI 853520) is an orally active and potent focal adhesion kinase (FAK) inhibitor (recombinant FAK IC₅₀=1 nM). Ifebemtinib shows anti-proliferative activity against cancer cells. Ifebemtinib inhibits FER Kinase and FES Kinase with IC₅₀s of 900 nM and 1040 nM, respectively .

HY-115928

M24	Bcl-2 Family	Cancer
M24 is a Mcl-1 selective inhibitor. M24 exhibits good binding affinity against Mcl-1 with K_i value of 0.33 μM. M24 exhibits good anti-proliferative activity and induce apoptosis in HepG2 cells .

HY-151480

HP590	STAT Apoptosis	Cancer
HP590 is an orally active, novel and potent STAT3 inhibitor (STAT3 luciferase activity: IC₅₀=27.8 nM; ATP inhibition: IC₅₀=24.7 nM). HP590 shows anti-proliferative activity to gastric cancer cells and induces apoptosis .

HY-151576

PRMT5:MEP50 PPI	Others	Cancer
PRMT5:MEP50 PPI is a novel PRMT5:MEP50 protein-protein interaction (PRMT5:MEP50 PPI) inhibitor, shows anti-tumor activity and anti-proliferative activity of lung and prostate cancer cells .

HY-17037S1

Pirenzepine-d8 dihydrochloride LS 519-d₈ dihydrochloride; Pirenzepin-d₈ dihydrochloride; Gastrozepin-d₈ dihydrochloride	Isotope-Labeled Compounds	Cancer
Pirenzepine-d₈ (LS 519-d₈; Pirenzepin-d₈) dihydrochloride is a deuterium labeled Pirenzepine (dihydrochloride) (HY-17037). Pirenzepine (LS 519) dihydrochloride is a selective M1 mAChR (muscarinic acetylcholine receptor) antagonist. Pirenzepine dihydrochloride reduces gastric acid secretion and reduces muscle spasm, can be used in peptic ulcers research. Pirenzepine dihydrochloride shows anti-proliferative activity to cancer cells .

HY-101870B

Uzansertib phosphate INCB053914 phosphate	Pim	Cancer
Uzansertib (INCB053914) phosphate is an orally active, ATP-competitive pan-PIM kinase inhibitor with IC₅₀s of 0.24 nM, 30 nM, 0.12 nM for PIM1, PIM2, PIM3, respectively. Uzansertib phosphate has broad anti-proliferative activity against a variety of hematologic tumor cell lines .

HY-101870

Uzansertib INCB053914	Pim	Cancer
Uzansertib (INCB053914) is an orally active, ATP-competitive pan-PIM kinase inhibitor with IC₅₀s of 0.24 nM, 30 nM, 0.12 nM for PIM1, PIM2, PIM3, respectively. Uzansertib has broad anti-proliferative activity against a variety of hematologic tumor cell lines .

HY-152019

EGFR/C797S-IN-1	EGFR	Cancer
EGFR/C797S-IN-1 is a potent EGFR-C797S inhibitor with an IC₅₀ value of 0.128 µM. EGFR/C797S-IN-1 shows anti-proliferative activity and anti-tumor activity. EGFR/C797S-IN-1 inhibits the expression of p-EGFR in a dose-dependent manner .

HY-150695

hCAIX/XII-IN-5	Carbonic Anhydrase Apoptosis	Cancer
hCAIX/XII-IN-5 (Coumarin 9a) a carbonic anhydrase (CA) inhibitor, and exhibits excellent hCA IX/XII selectivity (K_i=93.9 and 85.7 nM, respectively) over hCA I and hCA II. hCAIX/XII-IN-5 shows anti-proliferative activities to cancer cells. hCAIX/XII-IN-5 can delay cell cycle and induce apoptosis .

HY-U00345

CHK-IN-1

Checkpoint Kinase (Chk) Cancer

CHK-IN-1 is an inhibitor of CHK1 and CHK2, with anti-proliferative activities.

CHK-IN-1	Checkpoint Kinase (Chk)	Cancer
CHK-IN-1 is an inhibitor of CHK1 and CHK2, with anti-proliferative activities.

HY-146210

EGFR-IN-50	EGFR	Cancer
EGFR-IN-50 (Compound 9h) is a potent EGFR inhibitor against L858R resistance mutation (TEL-EGFR-L858R-BaF3: GI₅₀=8 nM, TEL-EGFR-T790M-L858R-BaF3: GI₅₀=6.03 μM). EGFR-IN-50 shows anti-proliferative activity to cancer cells .

HY-15856B

Flupentixol dihydrochloride Flupenthixol dihydrochloride	Dopamine Receptor PI3K Apoptosis	Neurological Disease Cancer
Flupentixol is an orally active D₁/D₂ dopamine receptor antagonist and new PI3K inhibitor (PI3Kα IC₅₀=127 nM). Flupentixol shows anti-proliferative activity to cancer cells and induces apoptosis. Flupentixol can also be used in schizophrenia, anxiolytic and depressive research .

HY-152091

Antiproliferative agent-18	Fungal	Infection Cancer
Antiproliferative agent-18 (Compound 5k) is an anti-proliferative agent. Antiproliferative agent-18 also displays moderate *anti-bacterial* and *anti-fungi* activity .

HY-148185

T01-1

ADC Cytotoxin Cancer

T01-1 is an anticancer agent (camptothecin derivative) with good anti-proliferative activity .
HY-153753

Wnt pathway inhibitor 4

Others Cancer

Wnt pathway inhibitor 4 (compound 16D) is an anticancer agent that has anti-proliferative activity .

T01-1	ADC Cytotoxin	Cancer
T01-1 is an anticancer agent (camptothecin derivative) with good anti-proliferative activity .

Wnt pathway inhibitor 4	Others	Cancer
Wnt pathway inhibitor 4 (compound 16D) is an anticancer agent that has anti-proliferative activity .

HY-157164

PROTAC EZH2 Degrader-2	PROTACs Histone Methyltransferase	Cancer
PROTAC EZH2 Degrader-2 (compound E-3P-MDM2), an EZH2 inhibitor, is a PROTAC composed of Tazemetostat (EPZ6438) and an E3 ligase system ligand. PROTAC EZH2 Degrader-2 degrades EZH2 in SU-DHL-6 cells in a dose-dependent manner, inhibits the expression of H3K27me3, and simultaneously degrades EED and SUZ12 proteins without affecting their mRNA levels. PROTAC EZH2 Degrader-2 has anti-cancer and anti-proliferative activity .

HY-N0202

Atractylenolide II 2 Publications Verification Asterolide	Apoptosis	Cancer
Atractylenolide II is a sesquiterpene compound isolated from the dried rhizome of Atractylodes macrocephala (Baizhu in Chinese); anti-proliferative activity.

HY-14543

Sertindole 2 Publications Verification Lu 23-174	5-HT Receptor Dopamine Receptor Adrenergic Receptor Autophagy	Neurological Disease Cancer
Sertindole (Lu 23-174) is an orally active 5-HT_2A, 5-HT_2C, dopamine D₂, and αl-adrenergic receptors antagonist. Sertindole shows antipsychotic activity and anti-proliferative activity to multiple cancer cells .

HY-B0421S

Mycophenolic acid-d3 Mycophenolate-d₃	Bacterial Apoptosis Fungal Antibiotic Endogenous Metabolite Isotope-Labeled Compounds Flavivirus	Others
Mycophenolic acid-d₃ is deuterium labeled Mycophenolic acid, which is an an immunosuppresant agent and has potent anti-proliferative activity.

HY-N3355

Lupeolic acid

Others Cancer

Lupeolic acid can be isolated from Boswellia sacra. Lupeolic acid has anti-proliferative activity and can be used in cancer research .
HY-N8477

Isolupalbigenin

NO Synthase Inflammation/Immunology

Isolupalbigenin is an inhibitor of NO. Isolupalbigenin has anti-proliferative activity on HL-60 cells with an IC₅₀ of 5.1 μM .

Lupeolic acid	Others	Cancer
Lupeolic acid can be isolated from Boswellia sacra. Lupeolic acid has anti-proliferative* activity and can be used in cancer research .*

Isolupalbigenin	NO Synthase	Inflammation/Immunology
Isolupalbigenin is an inhibitor of NO. Isolupalbigenin has anti-proliferative activity on HL-60 cells with an IC₅₀ of 5.1 μM .

HY-152090

Antiproliferative agent-17	Bacterial Sirtuin	Infection Cancer
Antiproliferative agent-17 is an antiproliferative agent. Antiproliferative agent-17 inhibits Gram-positive bacteria and has anticancer activity .

HY-144692

MEK/PI3K-IN-1	MEK PI3K PERK	Cancer
MEK/PI3K-IN-1 (compound 6r) is a potent MEK/PI3K inhibitor, with IC₅₀ values of 124 nM (MEK1), 130 nM (PI3Kα), and 236 nM (PI3Kδ), respectively. MEK/PI3K-IN-1 suppresses pAKT and pERK1/2 levels. MEK/PI3K-IN-1 shows anti-proliferative activity against tumor cell lines .

HY-144693

MEK/PI3K-IN-2	MEK PI3K PERK	Cancer
MEK/PI3K-IN-2 (compound 6s) is a potent MEK/PI3K inhibitor, with IC₅₀ values of 352 nM (MEK1), 107 nM (PI3Kα), and 137 nM (PI3Kδ), respectively. MEK/PI3K-IN-2 suppresses pAKT and pERK1/2 levels. MEK/PI3K-IN-2 shows anti-proliferative activity against tumor cell lines .

HY-146506

isoCA-4

Microtubule/Tubulin Cancer

isoCA-4, a Combretastatin A4 derivative, is a tubulin polymerization inhibitor. isoCA-4 has anti-proliferative activities .
HY-N10699

6-Methoxykaempferol

Others Cancer

6-Methoxykaempferol is a flavone that can be found in brazilian propolis. 6-Methoxykaempferol shows anti-proliferative activity for cancer cells .

isoCA-4	Microtubule/Tubulin	Cancer
isoCA-4, a Combretastatin A4 derivative, is a tubulin polymerization inhibitor. isoCA-4 has anti-proliferative activities .

6-Methoxykaempferol	Others	Cancer
6-Methoxykaempferol is a flavone that can be found in brazilian propolis. 6-Methoxykaempferol shows anti-proliferative activity for cancer cells .

HY-N11136

Schizolaenone C	Others	Cancer
Schizolaenone C is a natural product that can be found in Schizolaena hystrix. Schizolaenone C exhibits anti-proliferative and anti-oxidative activities .

HY-150654

WDR5-IN-5	Histone Methyltransferase	Cancer
WDR5-IN-5 is an orally active and selective inhibitor of WIN site of WD repeat domain 5 (WDR5). WDR5-IN-5 exhibits anti-proliferative activity towards cancer cells and good pharmacokinetics profile in mice. WDR5-IN-5 shows high affinity to WDR5 and the binding affinity K_i value <0.02 nM .

HY-N3527

Calyxin B

Others Cancer

Calyxin B can be extracted from the seeds of Alpinia blepharocalyx. Calyxin B has anti-proliferative activity and can be used in cancer research .

Calyxin B	Others	Cancer
Calyxin B can be extracted from the seeds of Alpinia blepharocalyx. Calyxin B has anti-proliferative activity and can be used in cancer research .

HY-157125

PI3Kα-IN-14	PI3K Apoptosis	Cancer
PI3Kα-IN-14 (compound F8) is a selective PI3Kα inhibitor with an IC₅₀ of 0.14 nM. PI3Kα-IN-14 induces a great decrease in mitochondrial membrane which caused cell cycle arrest at G1 phase and apoptosis in U87-MG cells. PI3Kα-IN-14 shows significant anti-proliferative activities against three tumor-derived cell lines (PC-3: IC₅₀ of 0.28 μM; HCT-116: IC₅₀ of 0.57 μM; and U87-MG: IC₅₀ of 1.37 μM) .

HY-N3428

Kamebanin

Others Cancer

Kamebanin can be isolated from the leaves of Isodon weisiensis C. Y. Wu. Kamebanin has anti-proliferative activity and can be used in cancer research .

Kamebanin	Others	Cancer
Kamebanin can be isolated from the leaves of Isodon weisiensis C. Y. Wu. Kamebanin has anti-proliferative activity and can be used in cancer research .

HY-W013332

3-Deazaadenosine 10+ Cited Publications	HIV	Infection Inflammation/Immunology
3-Deazaadenosine is an inhibitor of S-adenosylhomocysteine hydrolase, with a K_i of 3.9 µM; 3-Deazaadenosine has anti-inflammatory, anti-proliferative and anti-HIV activity.

HY-W013332A

3-Deazaadenosine hydrochloride 10+ Cited Publications	HIV	Infection Inflammation/Immunology
3-Deazaadenosine (hydrochloride) is an inhibitor of S-adenosylhomocysteine hydrolase, with a K_i of 3.9 µM; 3-Deazaadenosine has anti-inflammatory, anti-proliferative and anti-HIV activity.

HY-100757

CPUY074020	Histone Methyltransferase	Cancer
CPUY074020 is a potent and oral bioavailable inhibitor of histone methyltransferase G9a, with an IC₅₀ of 2.18 μM. CPUY074020 possesses anti-proliferative activity .

HY-152001

hCA IX-IN-2

Carbonic Anhydrase Cancer

hCA IX-IN-2 is a potent and selectively hCA IX inhibitor with an K_I value of 32.1 nM. hCA IX-IN-2 shows anti-proliferative activity .

hCA IX-IN-2	Carbonic Anhydrase	Cancer
hCA IX-IN-2 is a potent and selectively hCA IX inhibitor with an K_I value of 32.1 nM. hCA IX-IN-2 shows anti-proliferative activity .

HY-15605

Encorafenib 15+ Cited Publications LGX818	Raf	Cancer
Encorafenib (LGX818) is a highly potent BRAF inhibitor with selective anti-proliferative and apoptotic activity in cells expressing BRAF ^V600E (EC₅₀=4 nM).

HY-117737A

RRD-251	Raf Apoptosis	Cancer
RRD-251 is an inhibitor of retinoblastoma tumor suppressor protein (Rb)-Raf-1 interaction, with potent anti-proliferative, anti-angiogenic and anti-tumor activities .

HY-146889

ATX inhibitor 16	Others	Cancer
ATX inhibitor 16 is a potent ATX inhibitor with an IC₅₀ of 0.0021 µM. ATX inhibitor 16 shows excellent anti-proliferative activities in breast cancer cells .

HY-146890

ATX inhibitor 17	Others	Cancer
ATX inhibitor 17 is a potent ATX inhibitor with an IC₅₀ of 0.019 µM. ATX inhibitor 17 shows excellent anti-proliferative activities in breast cancer cells .

Cat. No.	Product Name	Target	Research Area

HY-N6689

Destruxin A	Antibiotic	Infection Cancer
Destruxin A (DA) is a cyclo-peptidic mycotoxin from the entomopathogenic fungus Metarhizium anisopliae, with insecticidal, anti-viral and antiproliferative activities .

HY-W039102

N-Fmoc-N,O-dimethyl-L-serine	Amino Acid Derivatives	Cancer
N-Fmoc-N,O-dimethyl-L-serine is a serine derivative that can be used for coibamide A synthesis. Coibamide A is a marine natural product with potent antiproliferative activity against human cancer cells .

HY-163001

Microcolin H	Autophagy p62 Atg8/LC3	Cancer
Microcolin H is a marine lipopeptide and phosphatidylinositol transfer protein ligand that targets PITPα/β. Microcolin H increases the conversion of LC3I to LC3II and reduces p62 levels in cancer cells, leading to autophagy cell death (Autophagy). Microcolin H effectively inhibits tumor development and has anti-proliferative activity in nude mouse subcutaneous tumor models .

HY-P2228

Chlamydocin	HDAC Apoptosis	Cancer
Chlamydocin, a fungal metabolite, is a highly potent HDAC inhibitor, with an IC₅₀ of 1.3 nM. Chlamydocin exhibits potent antiproliferative and anticancer activities. Chlamydocin induces apoptosis by activating caspase-3 .

HY-131923

DAPM	Notch	Cancer
DAPM is a Notch pathway inhibitor with anticancer activity and antiproliferative effects. DAPM effectively inhibits tubular adenoma development by inhibiting cell proliferation and inducing the expression of Krüppel-like factor 4 (KLF4) and p21 in human colon cancer cells .

HY-P3990

Coibamide A	VEGFR Autophagy Apoptosis	Cancer
Coibamide A, an N-methyl-stabilized cytotoxic depsipeptide, shows potent antiproliferative activity. Coibamide A induces autophagosome accumulation via an mTOR-independent mechanism. Coibamide A induces apoptosis. Coibamide A inhibits VEGFA/VEGFR2 expression and suppresses tumor growth in glioblastoma xenografts .

HY-P2282

APTSTAT3-9R 1 Publications Verification	STAT	Cancer
APTSTAT3-9R, a specific STAT3-binding peptide, inhibits STAT3 activation and downstream signaling by specifically blocking STAT3 phosphorylation. APTSTAT3-9R exerts antiproliferative effects and antitumor activity .

HY-16381

Pasireotide SOM230	Somatostatin Receptor	Endocrinology Cancer
Pasireotide (SOM230), a long-acting cyclohexapeptide somatostatin analogue, can improve agonist activity at somatostatin receptors (subtypes sst1/2/3/4/5, pK_i=8.2/9.0/9.1/<7.0/9.9, respectively). Pasireotide can suppress GH, IGF-I and ACTH secretion, indicating potential efficacy in acromegaly and Cushing's disease. Pasireotide also exhibits antisecretory, antiproliferative, and proapoptotic activity .

HY-16381A

Pasireotide acetate 1 Publications Verification SOM230 acetate	Somatostatin Receptor	Endocrinology Cancer
Pasireotide (SOM230) acetate, a long-acting cyclohexapeptide somatostatin analogue, can improve agonist activity at somatostatin receptors (subtypes sst1/2/3/4/5, pK_i=8.2/9.0/9.1/<7.0/9.9, respectively). Pasireotide acetate can suppress GH, IGF-I and ACTH secretion, indicating potential efficacy in acromegaly and Cushing's disease. Pasireotide acetate also exhibits antisecretory, antiproliferative, and proapoptotic activity .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2959

Brevilin A 3 Publications Verification	Structural Classification Classification of Application Fields Terpenoids Sesquiterpenes Source classification Euchresta horsfieldii (Lesch.) J. Benn. Plants Compositae Disease Research Fields Cancer	JAK STAT Apoptosis Autophagy
Brevilin A is an orally active STAT3/JAK inhibitor (STAT3 IC₅₀= 10.6 µM). Brevilin A shows anti-tumor activity, anti-proliferative activity to cancer cells, and can induce apoptosis and autophagy .

HY-N0202

Atractylenolide II 2 Publications Verification Asterolide	Classification of Application Fields Terpenoids Sesquiterpenes Source classification Astragalus caprinus L. Plants Compositae Disease Research Fields Cancer	Apoptosis
Atractylenolide II is a sesquiterpene compound isolated from the dried rhizome of Atractylodes macrocephala (Baizhu in Chinese); anti-proliferative activity.

HY-N10393

Vibsanin A	Structural Classification Natural Products Classification of Application Fields Viburnaceae Source classification Viburnum awabuki K. Koch Plants Disease Research Fields Cancer	PKC HSP
Vibsanin A, a protein kinase C (PKC) activator, exhibits anti-proliferative activity against human cancer cell lines. Vibsanin A is also a HSP90 inhibitor .

HY-N3355

Lupeolic acid	Structural Classification Ketones, Aldehydes, Acids Source classification Commiphora mukul (Hook. ex Stocks) Engl. Plants Burseraceae	Others
Lupeolic acid can be isolated from Boswellia sacra. Lupeolic acid has anti-proliferative* activity and can be used in cancer research .*

HY-N8477

Isolupalbigenin	Structural Classification Flavonoids Source classification Maclura tricuspidata Carriere Plants Moraceae Isoflavones	NO Synthase
Isolupalbigenin is an inhibitor of NO. Isolupalbigenin has anti-proliferative activity on HL-60 cells with an IC₅₀ of 5.1 μM .

HY-N11136

Schizolaenone C	Structural Classification Flavonoids Paulownia tomentosa (Thunb.) Steud. Flavonones Source classification Phenols Polyphenols Scrophulariaceae Plants	Others
Schizolaenone C is a natural product that can be found in Schizolaena hystrix. Schizolaenone C exhibits anti-proliferative and anti-oxidative activities .

HY-N3527

Calyxin B	Structural Classification Alpinia blepharocalyx K. Schum. Source classification Phenols Polyphenols Plants Zingiberaceae	Others
Calyxin B can be extracted from the seeds of Alpinia blepharocalyx. Calyxin B has anti-proliferative activity and can be used in cancer research .

HY-N3428

Kamebanin	Structural Classification Terpenoids Labiatae Source classification Artemisia monosperma Delile Diterpenoids Plants	Others
Kamebanin can be isolated from the leaves of Isodon weisiensis C. Y. Wu. Kamebanin has anti-proliferative activity and can be used in cancer research .

HY-N10670

Bursehernin Methylpluviatolide	Structural Classification Hernandia sonora Linn. other families Source classification Lignans Phenylpropanoids Plants	Apoptosis
Bursehernin (Methylpluviatolide) is an antitumor agent. Bursehernin induces Apoptosis and cell cycle arrest at G2/M phase. Bursehernin shows anti-proliferative activity .

HY-N12601

Diselaginellin B	Structural Classification Source classification Phenols Polyphenols Selaginella pulvinata (Hook. & Grev.) Maxim. Selaginellaceae Plants	Apoptosis
Diselaginellin B (compound 2) is a natural product isolated from Selaginella Pulvinata, which exhibits anti-proliferative, apoptosis-inducing and antimetastatic activities against human carcinoma hepatocellular cells .

HY-N10392

(S)-Erypoegin K	Structural Classification Flavonoids Classification of Application Fields Leguminosae Source classification Erythrina poeppigiana Plants Disease Research Fields Isoflavones Cancer	Apoptosis
(S)-Erypoegin K is a potent anticancer agent. (S)-Erypoegin K shows potent anti-proliferative activity against HL-60 cells. (S)-Erypoegin K induces apoptosis .

HY-N0578

Apigenin 7-glucoside 2 Publications Verification Apigenin-7-O-β-D-glucopyranoside; Cosmosiin; Apigetrin	Flavonoids Classification of Application Fields Flavones Source classification Dendranthema morifolium (Ramat.) Tzvel. Phenols Polyphenols Plants Compositae Disease Research Fields Cancer	Reactive Oxygen Species
Apigenin-7-glucoside (Apigenin-7-O-β-D-glucopyranoside) exhibits significant anti-proliferative and antioxidant activity and scavenges reactive oxygen species (ROS) .

HY-N3646

Cudratricusxanthone A	Structural Classification Flavonoids Source classification Maclura tricuspidata Carriere Plants Moraceae Other Flavonoids	Others
Cudratricusxanthone A is isolated from Cudrania tricuspidata, and has anti-inflammatory, hepatoprotective, and anti-proliferative activities. Cudratricusxanthone A inhibits osteoclast differentiation and function in RAW 264.7 cells and mouse bone marrow monocytes .

HY-N3845

Ergosterol peroxide	Natural Products Classification of Application Fields Orchidaceae Source classification Plants Disease Research Fields Inflammation/Immunology Anoectochilus elwesii	Bacterial
Ergosterol peroxide is a steroid derivative and can be isolated from a variety of fungi, yeast, lichens or sponges. Ergosterol peroxide has anti-tumour, proapoptotic, anti-inflammatory, anti-mycobacterial, and anti-proliferative activities .

HY-126423

Isorhamnetin 3-glucuronide Isorhamnetin 3-O-glucuronide	Structural Classification Flavonoids Flavones Source classification Endogenous metabolite	Others
Isorhamnetin 3-glucuronide is a potent anticancer agent. Isorhamnetin 3-glucuronide shows anti-proliferative activity. Isorhamnetin 3-glucuronide induces Apoptosis and cell cycle arrest at S-phase .

HY-N7640

Deoxylimonin	Triterpenes Microorganisms Classification of Application Fields Citrus paradisi Macf. Terpenoids Source classification Rutaceae Plants Disease Research Fields Inflammation/Immunology	Others
Desoxylimonin is an orally active triterpenoid compound found from grapefruit seed. Desoxylimonin shows anti-proliferative activities to breast cancer cells. Desoxylimonin derivatives shows better anticancer, analgesic and anti-inflammatory activity than the lead compound .

HY-N3005

Britannin 1 Publications Verification	Phyllodium pulchellum (L.) Desv. Classification of Application Fields Terpenoids Sesquiterpenes Source classification Plants Compositae Inflammation/Immunology Disease Research Fields	Apoptosis Autophagy
Britannin, isolated from Inula aucheriana, is a sesquiterpene lactone. Britannin induces apoptosis and autophagy by activating AMPK regulated by ROS in liver cancer cells. Britannin has anti-proliferative and anti-inflammatory activities .

HY-N7015

Zerumbone	Infection Structural Classification Natural Products Zingiber zerumbet Classification of Application Fields Source classification Plants Disease Research Fields Zingiberaceae	EBV Caspase Apoptosis Bacterial
Zerumbone is an orally active natural cyclic sesquiterpene and can be isolated from Zingiber zerumbet. Zerumbone has anti-proliferative, anti-inflammation, anti-cancer, anti-bacterial and anti-mutagenic activity .

HY-120607

Chevalone C	Infection Triterpenes Microorganisms Classification of Application Fields Terpenoids Source classification Disease Research Fields	Parasite
Chevalone C, a meroterpenoid fungal metabolite, shows antimalarial activity with IC₅₀ value of 25.00 μg/mL. Chevalone C has anti-proliferative activity on colon HCT116, liver HepG2 and melanoma A375 cancer cell lines .

HY-N3451

Isothymusin	Structural Classification Flavonoids Classification of Application Fields Flavones Labiatae Source classification Balsamorhiza macrophylla Nutt. Plants Disease Research Fields Cancer	Lipoxygenase
Isothymusin is a potent anti-oxidant agent. Isothymusin shows radical scavenging activities. Isothymusin shows anti-proliferative activities in cancer cell lines. Isothymusin inhibited the enzymes associated with the promotion stage of cancer, including cycloxygenase- 2 and lipoxygenase-5 .

HY-N12503

Patuletin	Structural Classification Flavonols Flavonoids Source classification Amaranthaceae Plants Spinacia oleracea L.	Apoptosis Caspase
Patuletin is a flavonol, that can be isolated from the flowers of Tagetes patula. Patuletin shows anti-proliferative activity against cancer cells. Patuletin causes significant nuclear fragmentation and has a great capacity to induce caspase-3 activation .

HY-N0448

10-Gingerol	Zingiber officinale Roscoe Natural Products Monophenols Classification of Application Fields Source classification Phenols Plants Disease Research Fields Inflammation/Immunology Zingiberaceae	Others
10-Gingerol is a major pungent constituent in the ginger oleoresin from fresh rhizome, with anti-inflammatory, antioxidant and anti-proliferative activities. 10-Gingerol inhibits the proliferation of MDA-MB-231 tumor cell line with an IC₅₀ of 12.1 μM .

HY-N7072

Grape seed extract 1 Publications Verification	Natural Products Classification of Application Fields Source classification Vitis vinifera cv. Zalema Metabolic Disease Plants Vitaceae Disease Research Fields Inflammation/Immunology	Apoptosis
Grape seed extract is a natural product, with anti-inflammatory and anti-proliferative effects. Grape seed extract shows inhibitory activity on the fat-metabolizing enzymes pancreatic lipase and lipoprotein lipase. Grape seed extract induces apoptotic in human colorectal cancer cells .

HY-N2920

β-Amyrenonol 11-Oxo-β-amyrin	Natural Products Classification of Application Fields Source classification Myrtaceae Rhodomyrtus tomentosa Plants Disease Research Fields Inflammation/Immunology	Cytochrome P450
β-Amyrenonol (11-Oxo-β-amyrin), an oleanolic-type triterpenoid in licorice roots, is a precursor of Glycyrrhetinic acid. β-Amyrenonol has anti-proliferative and anti-inflammatory activities, and β-Amyrenonol could function as the skeleton for the synthesis of many triterpenoids .

HY-N6797

Meleagrin	Infection Alkaloids Microorganisms Classification of Application Fields Source classification Disease Research Fields Indole Alkaloids	Bacterial c-Met/HGFR Antibiotic
Meleagrin is a roquefortine C-derived alkaloid produced by fungi of the genus Penicillium and has antimicrobial and anti-proliferative activities. Meleagrin is a class of FabI inhibitor. Meleagrin is a lead c-Met inhibitory entity useful for the control of c-Met-dependent metastatic and invasive breast malignancies .

HY-N3523

3-O-Beta-D-Glucopyranosylplatycodigenin	Triterpenes Classification of Application Fields Terpenoids Source classification Platycodon grandiflorus (Jacq.) A. DC. Campanulaceae Plants Disease Research Fields Cancer	Others
3-O-Beta-D-Glucopyranosylplatycodigenin is an oleanane-type triterpenoid isolated from roots of Platycodon grandiflorum. 3-O-Beta-D-Glucopyranosylplatycodigenin exhibits anti-proliferative activities against HSC-T6 cell line with an IC₅₀ of 13.36 μM .

HY-N0181A

Lumisterol 9β,10α-Ergosterol	Structural Classification Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	Endogenous Metabolite
Lumisterol (9β,10α-Ergosterol), a steroid compound, is the (9β,10α)-stereoisomer of Ergosterol (HY-N0181). Lumisterol is a photoprotective agent against UVB-induced DNA damage and anti-proliferative activities .

HY-N6635

trans-Nerolidol	Structural Classification Natural Products Source classification Celastraceae Celastrus angulatus Maxim. Plants	Fungal
trans-Nerolidol is a sesquiterpene alcohol. It can be isolated from f aerial parts of Warionia saharae ex Benth. trans-Nerolidol improves the anti-proliferative effect of Doxorubicin (HY-15142A) against intestinal cancer cells in vitro. trans-Nerolidol also has anti-fungal activity .

HY-A0143A

Dihomo-γ-linolenic acid sodium DGLA sodium; all-cis-8,11,14-Eicosatrienoic acid sodium	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	Endogenous Metabolite
Dihomo-γ-linolenic acid (DGLA; all-cis-8,11,14-Eicosatrienoic acid) sodium is a 20-carbon ω-6 fatty acid, with anti-inflammatory and anti-proliferative activities. Dihomo-γ-linolenic acid (sodium) attenuates atherosclerosis in the apolipoprotein E deficient mouse model system .

HY-N8519

Urdamycin B	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Bacterial Fungal Antibiotic
Urdamycin B is an antibiotic that effectively inhibits fungi and bacteria. Urdamycin B also exhibits anti-proliferative activity against mouse leukemia cells L1210. Urdamycin B can be obtained from the metabolic products of Streptomyces fradiae. Urdamycin B can be used for research on cancer as well as bacterial and fungal infections .

HY-13065

Isobavachalcone 5+ Cited Publications Corylifolinin; Isobacachalcone	Structural Classification Classification of Application Fields Source classification Plants Chalcones Flavonoids Leguminosae Phenols Polyphenols Psoralea corylifolia L. Disease Research Fields Glycyrrhiza uralensis Fisch. Cancer	Akt Reactive Oxygen Species Apoptosis Autophagy
Isobavachalcone (Corylifolinin) is derived from Psoralea corylifolia Linn. and is a potent inhibitor of Akt signaling pathway, which induces apoptosis in human cancer cells (Inhibits OVCAR-8 cell growth with an IC₅₀ value of 7.92 μM). Isobavachalcone also induces Reactive Oxyen Species (ROS) generation in OVCAR-8 cells and has exhibit cancer anti-promotive and anti-proliferative activity .

HY-163001

Microcolin H	Microorganisms Source classification	Autophagy p62 Atg8/LC3
Microcolin H is a marine lipopeptide and phosphatidylinositol transfer protein ligand that targets PITPα/β. Microcolin H increases the conversion of LC3I to LC3II and reduces p62 levels in cancer cells, leading to autophagy cell death (Autophagy). Microcolin H effectively inhibits tumor development and has anti-proliferative activity in nude mouse subcutaneous tumor models .

HY-N2787

8-Prenylnaringenin 1 Publications Verification	Flavonoids Classification of Application Fields Humulus lupulus L. Flavonones Source classification Phenols Polyphenols Plants Moraceae Disease Research Fields Cancer	Apoptosis
8-prenylnaringenin is a prenylflavonoid isolated from hop cones Humulus lupulus, with cytotoxicity. 8-prenylnaringenin has anti-proliferative activity against HCT-116 colon cancer cells via induction of intrinsic and extrinsic pathway-mediated apoptosis. 8-Prenylnaringenin also promotes recovery from immobilization-induced disuse muscle atrophy through activation of the Akt phosphorylation pathway in mice .

HY-N12253

(19R)-13-Deoxy-19-hydroxyenmein	Structural Classification Terpenoids Labiatae Source classification Diterpenoids Ambrosia camphorata (Greene) W.W.Payne Plants	Others
(19R)-13-Deoxy-19-hydroxyenmein is the parent compound of enmein-type diterpenoid analogs. (19R)-13-Deoxy-19-hydroxyenmein has *anti-proliferative* activities with IC₅₀ values of 0.41, 0.85, 0.43, 1.89 μM against human cancer cell lines K562, MGC-803, CaEs-17, and Bel-7402, respectively .

HY-N8676

Antiproliferative agent-29	Triterpenes Structural Classification Terpenoids Zygophyllaceae Source classification Peganum harmala Linn. Plants	Others
Antiproliferative agent-29 (Compound 16) is a triterpenoid isolated from the seeds of Peganum harmala L. Antiproliferative agent-29 has antiproliferative activity and has potential for cancer research .

HY-N8677

Antiproliferative agent-28	Triterpenes Structural Classification Terpenoids Zygophyllaceae Source classification Peganum harmala Linn. Plants	Others
Antiproliferative agent-28 (Compound 14) is a triterpenoid isolated from the seeds of Peganum harmala L. Antiproliferative agent-28 has antiproliferative activity and has potential for cancer research .

HY-N10067

Micromonosporamide A	Alkaloids Structural Classification Microorganisms Classification of Application Fields Other Alkaloids Source classification Disease Research Fields Cancer	Others
Micromonosporamide A exhibits glutamine-dependent antiproliferative activity.

HY-N7279

Epiaschantin (+)-Epiaschantin	Structural Classification other families Hernandia nymphaeifolia (C. Presl) Kubitzki Source classification Lignans Phenylpropanoids Plants	Others
Epiaschantin is an anticancer agent. Epiaschantin shows antiproliferative activity .

HY-N3988

Hannokinol	Structural Classification Amomum tsaoko Crevost et Lemarie Source classification Phenols Polyphenols Plants Zingiberaceae	Others
Hannokinol is a potent anti-tumor agent. Hannokinol shows antiproliferative activity. Hannokinol shows antioxidant activities .

HY-N12282

Isovitexin 2′′-O-rhamnoside	Structural Classification Polysaccharides Flavonoids Tetrastigma hemsleyanum Diels et Gilg Flavones Source classification Plants Vitaceae Saccharides	Others
Isovitexin 2′′-O-rhamnoside, a phenolic, has antioxidant and antiproliferative activities .

HY-N0743

Senkyunolide A 2 Publications Verification	Natural Products Classification of Application Fields Source classification Dicerothamnus rhinocerotis Plants Umbelliferae Disease Research Fields Cancer	Others
Senkyunolide A, isolated from Ligusticum chuanxiong Hort, has cytoprotective and antiproliferative activities. Anti-tumor activity .

HY-N4313

Eriosematin	Monophenols Classification of Application Fields Leguminosae Flemingia philippinensis Merr. et Rolfe Ketones, Aldehydes, Acids Source classification Phenols Metabolic Disease Plants Disease Research Fields	Apoptosis
Eriosematin is a compound from the roots of Flemingia philippinensis with antiproliferative activity and apoptosis-inducing property .

HY-N11916

Kadsuphilin A	Structural Classification Natural Products Source classification Kadsura philippinensis Elmer Plants Schisandraceae	Others
Kadsuphilin A can be extracted from Kadsura coccinea (Lem.) and has weak antiproliferative activity .

HY-N0009

Geniposide 5+ Cited Publications	Structural Classification Iridoids Terpenoids Source classification Rubiaceae Plants Gardenia jasminoides Ellis	Amyloid-β Influenza Virus
Geniposide is an iridoid glucoside extracted from Gardenia jasminoidesEllis fruits; exhibits a varity of biological activities such as anti-diabetic, antioxidative, antiproliferative and neuroprotective activities.

HY-N6689

Destruxin A	Infection Structural Classification Microorganisms Classification of Application Fields Cyclopeptides Source classification Disease Research Fields Biological Pesticide Research Agricultural Research	Antibiotic
Destruxin A (DA) is a cyclo-peptidic mycotoxin from the entomopathogenic fungus Metarhizium anisopliae, with insecticidal, anti-viral and antiproliferative activities .

HY-N0944

(-)-Heraclenol	Natural Products other families Classification of Application Fields Source classification Plants Disease Research Fields Cancer	Others
(-)-Heraclenol is a derivative of furocoumarin isolated from Ducrosia anethifolia. (-)-Heraclenol shows antiproliferative and cytotoxic activities on cancer cell lines .

HY-W000427

Ethyl Orsellinate	Infection Classification of Application Fields Usnea diffracta Vain. Source classification Phenols Polyphenols Plants Disease Research Fields Usneaceae	Bacterial
Ethyl orsellinate is a lichen metabolite and a derivative of lecanoric acid with antiproliferative and antitumour activities . Ethyl Orsellinate is against A. salina for the cytotoxic activity with an LC₅₀ of 495 μM .

HY-N7611

7-Prenyloxyaromadendrin	Flavanonols Flavonoids other families Pterocaulon alopecuroides Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields Cancer	Others
7-Prenyloxyaromadendrin is a flavonoid from Pterocaulon alopecuroides with antitumor activity. 7-Prenyloxyaromadendrin shows good antiproliferative activity in tumor cell lines .

HY-W005130

2,4,6-Trihydroxybenzaldehyde	Monophenols Animals Phenols	NF-κB
2,4,6-Trihydroxybenzaldehyde is an orally active NF-ĸB inhibitor. 2,4,6-Trihydroxybenzaldehyde shows anti-tumor activity, anti-cancer cell proliferative activity and anti-obesity activity .

HY-N6871

Abietic acid	Infection Structural Classification Colophony Classification of Application Fields Pinaceae Ketones, Aldehydes, Acids Metabolic Disease Plants Inflammation/Immunology Disease Research Fields	Bacterial
Abietic acid, a diterpene isolated from Colophony, possesses antiproliferative, antibacterial, and anti-obesity properties. Abietic acid inhibits lipoxygenase activity for allergy treatment .

Cat. No.	Product Name	Chemical Structure

HY-17037S1

Pirenzepine-d8 dihydrochloride

Pirenzepine-d₈ (LS 519-d₈; Pirenzepin-d₈) dihydrochloride is a deuterium labeled Pirenzepine (dihydrochloride) (HY-17037). Pirenzepine (LS 519) dihydrochloride is a selective M1 mAChR (muscarinic acetylcholine receptor) antagonist. Pirenzepine dihydrochloride reduces gastric acid secretion and reduces muscle spasm, can be used in peptic ulcers research. Pirenzepine dihydrochloride shows anti-proliferative activity to cancer cells .

HY-B0421S

Mycophenolic acid-d3

Mycophenolic acid-d₃ is deuterium labeled Mycophenolic acid, which is an an immunosuppresant agent and has potent anti-proliferative activity.

HY-A0143S

Dihomo-γ-linolenic acid-d6
Dihomo-γ-linolenic acid-d₆ (DGLA-d₆) is the deuterium labeled Dihomo-γ-linolenic acid. Dihomo-γ-linolenic acid (all-cis-8,11,14-Eicosatrienoic acid) is a 20-carbon ω-6 fatty acid, with anti-inflammatory and anti-proliferative activities. Dihomo-γ-linolenic acid attenuates atherosclerosis in the apolipoprotein E deficient mouse model system[1][2][3].

HY-N0005S

Curcumin-d6
Curcumin-d₆is a deuterium labeled Curcumin (Turmeric yellow). Curcumin (Turmeric yellow) is a natural phenolic compound with diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. Curcumin is an inhibitor of p300 histone acetylatransferase (HATs) and also shows inhibitory effects on NF-κB and MAPKs.

HY-15605S

Encorafenib-13C,d3
Encorafenib- ¹³C,d₃ is the ¹³C- and deuterium labeled Encorafenib. Encorafenib (LGX818) is a highly potent BRAF inhibitor with selective anti-proliferative and apoptotic activity in cells expressing BRAFV600E (EC50=4 nM).

HY-142283AS

Dosimertinib mesylate
Dosimertinib-d₅ (mesylate) is a potent and orally active EGFR inhibitor. Dosimertinib-d₅ (mesylate) decreases the expression of p-EGFR and p-ERK protein levels. Dosimertinib-d₅ (mesylate) shows antiproliferative and anti-tumor activity. Dosimertinib-d₅ (mesylate) has the potential for the research of non-small-cell lung cancer (NSCLC)[1].

HY-B0965AS

Thioridazine-d3 hydrochloride

Thioridazine-d₃ (hydrochloride) is the deuterium labeled Thioridazine. Thioridazine, an antagonist of the dopamine receptor D2 family proteins, exhibits potent anti-psychotic and anti-anxiety activities. Thioridazine is also a potent inhibitor of PI3K-Akt-mTOR signaling pathways with anti-angiogenic effect. Thioridazine shows antiproliferative and apoptosis induction effects in various types of cancer cells, with specificity on targeting cancer stem cells (CSCs)[1][2][3][4].

HY-142283

Dosimertinib
Dosimertinib-d₃-d₃ is a potent and orally active EGFR inhibitor. Dosimertinib-d₃-d₃ decreases the expression of p-EGFR and p-ERK protein levels. Dosimertinib-d₃-d₃ shows antiproliferative and anti-tumor activity. Dosimertinib-d₃-d₃ has the potential for the research of non-small-cell lung cancer (NSCLC)[1].

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